This study investigates the acoustic absorption performance of various infill patterns in Fused Filament Fabrication (FFF) 3D printing utilizing polylactic acid (PLA). Recognizing the gap in existing research regarding the influence of geometric configurations on sound absorption efficiency, we analyzed multiple designs, including standard patterns (aligned rectilinear, honeycomb, triangles, gyroid, and grid) and custom Kresling origami (KO) structures. Our findings revealed that the KO patterns achieved average absorption coefficients ranging from 0.35 to 0.85 across the frequency spectrum of 2000 to 5000 Hz, significantly outperforming traditional designs, which exhibited coefficients between 0.10 and 0.40. However, we also noted an absorption dip around 3000 Hz, where the performance declined to an average coefficient of 0.20. This research illustrates how 3D printing can be leveraged to create intricate internal geometries that enhance sound absorption capabilities. Furthermore, it provides insights into how design parameters—such as infill density, cell size, and wall thickness—affect acoustic performance. The implications of this work extend to diverse applications requiring effective noise management, including environmental noise control and HVAC systems. Future research will focus on optimizing geometric factors and exploring alternative materials, thereby paving the way for the development of advanced, sustainable acoustic absorbers tailored for a wide range of applications.