Hybrid additive manufacturing can be troublesome when implementing new processes using existing hardware which makes this research field increasingly prominent. Even after the integration of crucial hardware components necessary for Hybrid AM, there is no suitable software package capable of efficient toolpath planning of multi-material and multi-functional materials. Topology-optimized design would benefit from a planned process using hybrid manufacturing with simple electronics integration because of the need for optimized functional structures in the aerospace and automotive industries. The scope of this research takes multi-axis CNC toolpath strategies for syringe-deposited conductive inks over additively manufactured topology-optimized structures. A hybrid manufacturing machine utilizing multiple tools is used for the implementation of drone frame design with embedded signal and power transfer for electronic components. Process parameter configuration for machine hardware and CAM toolpath tolerancing with machine simulations are discussed in this paper. The resistance and adhesion of the hybrid multi-material 5D electrical interconnect structures are studied and compared alongside existing electronics manufacturing processes.